Django and Flask are the most popular frameworks for full stack development in Python. Django offers a robust framework with built-in features, while Flask is lightweight and more flexible, ideal for smaller applications.

When considering Python frameworks for full stack development, Django and Flask stand out as the most popular choices. Django is a high-level framework that encourages rapid development and clean, pragmatic design. It includes numerous built-in features such as an admin panel, ORM (Object-Relational Mapping), and authentication mechanisms, making it suitable for larger projects where time-to-market is crucial. On the other hand, Flask is a micro-framework that is minimalist and modular, allowing developers to choose their components. This flexibility makes Flask ideal for smaller applications or projects where developers want more control over the architecture. Other notable frameworks include FastAPI, which is excellent for building APIs quickly, and Pyramid, which is designed for larger applications with complex requirements. Choosing the right framework often depends on project size, team expertise, and specific needs.