Django is a high-level web framework that follows the 'batteries-included' approach, offering numerous built-in features. Flask, on the other hand, is a micro-framework that provides more flexibility and is suitable for smaller projects.

The primary difference between Django and Flask lies in their approach to web development. Django is a high-level web framework that follows the 'batteries-included' philosophy, meaning it comes with a plethora of built-in features and tools that simplify the development process. This includes an ORM, an admin interface, authentication, and templating systems, making it an excellent choice for large-scale applications that require rapid development and complex functionality. Django's structure encourages the use of best practices, which can be beneficial for new developers. In contrast, Flask is a micro-framework that provides a lightweight and flexible option for web development. It does not impose a specific structure, allowing developers to choose the components they need, which can be ideal for smaller projects or when building APIs. Flask encourages simplicity and fine-grained control, making it a great choice for developers who prefer a more hands-on approach. Ultimately, the choice between Django and Flask often comes down to project requirements; Django is more suitable for larger applications requiring extensive features, while Flask shines in simpler, more customizable projects.